18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomographic Imaging Detects Aortic Wall Inflammation in Patients With Repaired Coarctation of Aorta
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Patients with surgically repaired coarctation of aorta (RCoA) are at increased cardiovascular mortality risk. Inflammation is an important element in RCoA.1,2 Positron emission tomography/computed tomography (PET/CT) with 18F-fluorodeoxyglucose (18F-FDG) is the gold-standard imaging modality to noninvasively assess vascular inflammation in vivo. In this pilot study, we explore the value of 18F-FDG PET/CT imaging in assessing aortic wall inflammation in RCoA subjects.
A total of 15 patients with successful RCoA and 15 age- and sex-matched control subjects who have undergone treatment for lymphoma—a potentially high cardiovascular risk group—but were disease-free at the time of enrollment underwent 18F-FDG PET/CT to evaluate aortic wall inflammation. RCoA patients also underwent measurement of arterial elastic properties (augmentation index and carotid–femoral pulse wave velocity) by SphygmoCor (AtCor Medical, Sydney, Australia). The central arterial blood pressure was derived from the use of a generalized transfer function. Plasma levels of IL-6 (interleukin-6), TGF-β (transforming growth factor-β), and macrophage colony-stimulating factor were determined as markers of systemic inflammation and aortic wall remodeling. Patients with hypercholesterolemia or diabetes mellitus were excluded. To test the hypothesis that aortic coarctation is associated with increased aortic wall inflammation even in the absence of adverse hemodynamic burden to the aorta, patients with recoarctation were also …