Letter by Zakeri and Redfield Regarding Article, “Influence of Left Atrial Function on Exercise Capacity and Left Ventricular Function in Patients With Heart Failure and Preserved Ejection Fraction”
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To the Editor:
We read with great interest the study by von Roeder et al1 which highlighted a pivotal role for left atrial (LA) functional remodeling in human heart failure with preserved ejection fraction (HFpEF).1 The authors report impaired LA conduit strain occurring at an early stage of HFpEF, where 1/3rd of patients had a normal brain type natriuretic peptide, and left ventricular (LV) concentric remodeling was apparently absent (equivalent end-diastolic volume and LV mass index between HFpEF and controls).