Radiomics to Identify High-Risk Atherosclerotic Plaque From Computed Tomography
The Power of Quantification
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Measure what is measurable, and make measurable what is not so.
—Galileo Galilei (1564–1642)
Coronary computed tomographic angiography (CTA) allows noninvasive assessment of the coronary anatomy and is increasingly used for the assessment of luminal stenosis. The time period during which CTA matured (starting in the early 1990s and continuing to this day) also coincides with dramatic increases in computational power by standard off-the-shelf computer workstations and novel methodological developments, which enable many applications in the field of medical imaging. Radiomics, which includes the extraction and mining of a large number of quantitative features from imaging, and is usually applied to quantify tumor phenotype characteristics,1 is one of these applications.
See Article by Kolossváry et al
Beyond stenosis, CTA also allows noninvasive assessment of atherosclerotic plaque, including plaque composition, distribution, and burden, as well as coronary artery remodeling. Several qualitative high-risk plaque characteristics, including positive or outward coronary artery remodeling and low-attenuation plaque, have been shown to independently predict future major adverse cardiovascular events. In a study of 1059 patients undergoing CTA with …