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Original Articles

Strain-Encoded Cardiac MRI as an Adjunct for Dobutamine Stress Testing

Incremental Value to Conventional Wall Motion Analysis

Grigorios Korosoglou, MD; Dirk Lossnitzer, MD; Dieter Schellberg, PhD; Antje Lewien, MS; Angela Wochele, RN; Tim Schaeufele, MD; Mirja Neizel, MD; Henning Steen, MD; Evangelos Giannitsis, MD; Hugo A. Katus, MD and Nael F. Osman, PhD

From the Departments of Cardiology (G.K., D.L., A.L., A.W., T.S., M.N., H.S., E.G., H.A.K.), and Psychosomatic and General Internal Medicine (D.S.), University of Heidelberg, Heidelberg, Germany; and Russell H. Morgan Department of Radiology and Radiological Science (N.F.O.), Johns Hopkins University School of Medicine, Baltimore, Md.

Correspondence to Grigorios Korosoglou, MD, Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, 69120 Germany. E-mail gkorosoglou{at}hotmail.com

Received May 3, 2008; accepted December 10, 2008.

Background— High-dose dobutamine stress MRI is safe and feasible for the diagnosis of coronary artery disease (CAD) in humans. However, the assessment of cine scans relies on the visual interpretation of regional wall motion, which is subjective. Recently, strain-encoded MRI (SENC) has been proposed for the direct color-coded visualization of myocardial strain. The purpose of our study was to compare the diagnostic value of SENC with that provided by conventional wall motion analysis for the detection of inducible ischemia during dobutamine stress MRI.

Methods and Results— Stress-induced ischemia was assessed by wall motion analysis and by SENC in 101 patients with suspected or known CAD and in 17 healthy volunteers who underwent dobutamine stress MRI in a clinical 1.5-T scanner. Quantitative coronary angiography deemed as the standard reference for the presence or absence of significant CAD (50% diameter stenosis). On a coronary vessel level, SENC detected inducible ischemia in 86 of 101 versus 71 of 101 diseased coronary vessels (P<0.01 versus cine) and showed normal strain response in 189 of 202 versus 194 of 202 vessels with <50% stenosis (P=NS versus cine). On a patient level, SENC detected inducible ischemia in 63 of 64 versus 55 of 64 patients with CAD (P<0.05 versus cine) and showed normal strain response in 32 of 37 versus 34 of 37 patients without CAD (P=NS versus cine). Quantification analysis demonstrated a significant correlation between strain rate reserve and coronary artery stenosis severity (r²=0.56, P<0.001), and a cutoff value of strain rate reserve of 1.64 was deemed as a highly accurate marker for the detection of 50% stenosis (area under the curve, 0.96; SE, 0.01; 95% CI, 0.94 to 0.98; P<0.001).

Conclusions— The direct color-coded visualization of strain on MR images is a useful adjunct for dobutamine stress MRI, which provides incremental value for the detection of CAD compared with conventional wall motion readings on cine images.

Key Words: myocardial strain response • strain-encoded MRI • dobutamine stress MRI • inducible ischemia • strain rate reserve • coronary disease • inotropic agents

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CLINICAL PERSPECTIVE

Drs Korosoglou and Lossnitzer contributed equally to this study.

The online-only Data Supplement is available at http://circimaging.ahajournals.org/cgi/content/full/10.1161/CIRCIMAGING.108.790105/DC1.

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Strain-Encoded Cardiac MRI as an Adjunct for Dobutamine Stress Testing: Incremental Value to Conventional Wall Motion Analysis

Grigorios Korosoglou, Dirk Lossnitzer, Dieter Schellberg, Antje Lewien, Angela Wochele, Tim Schaeufele, Mirja Neizel, Henning Steen, Evangelos Giannitsis, Hugo A. Katus, and Nael F. Osman
Circ Cardiovasc Imaging 2009 2: 132-140. [Abstract] [Full Text] [PDF]

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